MRI differential diagnosis of early-stage lung invasive adenocarcinoma appearing as ground-glass nodule
10.13929/j.1003-3289.201808150
- Author:
Ning ZHANG
1
Author Information
1. Department of CT & MRI, Fourth Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
Adenocarcinoma of lung;
Diagnosis, differential;
Magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2019;35(3):352-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate value of MRI in differential diagnosis of early-stage invasive lung adenocarcinoma appearing as ground-glass nodule. Methods MRI findings in 34 patients with lung adenocarcinoma appearing as ground-glass nodule were analyzed retrospectively. According to the pathology, the patients were divided into non-invasive adenocarcinoma group (including atypical adenomatous hyperplasia, adenocarcinoma in situ and minimally invasive adenocarcinoma, n=15) and invasive adenocarcinoma group (n=19). The maximum diameter, T2WI signal intensity and ADC value were measured and compared between the 2 groups. ROC curves were used to evaluate the efficacy of differential diagnosis of invasive adenocarcinoma. Results The maximum diameter of lesions in non-invasive adenocarcinoma group was significantly less than that in invasive adenocarcinoma group ([9.91±2.63]mm vs [13.12±2.71]mm, P<0.01). T2WI signal intensity of lesions in non-invasive adenocarcinoma group was significantly lower than that in invasive adenocarcinoma group (92.97±8.33 vs 113.57±22.88, P<0.01). ADC value in non-invasive adenocarcinoma group was also significantly lower than that in invasive adenocarcinoma group ([0.98±0.22]×10-3 mm2/s vs [1.34±0.31]×10-3 mm2/s, P=0.01). ROC curve showed that the AUC of the maximum diameter was the highest, which value was 0.791, and the optimal cut-off value was 11.52 mm, with sensitivity of 73.72%, specificity of 73.33%. Conclusion The maximum diameter, T2WI signal intensity and ADC value are valuable for differential diagnosis of lung invasive adenocarcinoma from non-invasive lesions.
