Diffusion kurtosis imaging and intravoxel incoherent motion DWI parameters measured with different methods for breast masses
10.13929/j.1003-3289.201811062
- Author:
Lifang SI
1
Author Information
1. Department of Radiology, Beijing Chao-yang Hospital, Capital Medical University
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Diagnosis, differential;
Diffusion magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2019;35(5):706-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the value of diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) parameters measured using different methods in differentiating benign and malignant breast mass lesions. Methods Totally 59 patients (62 mass lesions) with breast mass lesions verified by pathologic results or follow up were enrolled. All patients underwent MR scanning, including dynamic contrast-enhanced MRI, IVIM DWI and DKI. ROI were placed at the most enhanced location, and the parameters of standard ADC (ADCstand), slow ADC (ADCslow), mean kurtosis (MK) and mean diffusion (MD) were measured. The whole lesions on the maximum slice were drawn as ROI, and the ADCstand-max, ADCslow-max, ADCfast-max, MK-max, MD-max were obtained. The differences of these parameters between benign and malignant breast lesions were analyzed. The diagnostic performance of these parameters was evaluated by ROC curve, the AUC was compared between the two methods. Results: There were 26 malignant lesions and 36 benign lesions. All the parameters (ADCstand, ADCstand-max, ADCslow, ADCslow-max, MK, MK-max, MD, MD-max) were significantly different between malignant and benign lesions (all P<0.001). AUC of ADCslow combined MK was the highest (0.915), with the sensitivity of 88.9% and specificity of 84.6%. The differences of AUC between ADCstand and ADCstand-max (Z=1.465, P=0.143), ADCslow and ADCslow-max (Z=1.013, P=0.311), MK and MK-max (Z=1.021, P=0.307), MD and MD-max (Z=1.428, P=0.153) were not statistically significant. Conclusion: For breast mass lesions, all DKI and IVIM DWI parameters are helpful to differentiating malignancy from benign lesions, and these parameters measured with different methods show equal diagnostic efficiency.
