Quantitative analysis of 1H-MRS in differential diagnosis of cerebral alveolar echinococcosis and brain metastases
10.13929/j.1003-3289.201809067
- Author:
Dan ZHANG
1
Author Information
1. Imaging Center, the First Affiliated Hospital of Xinjiang Medical University
- Publication Type:Journal Article
- Keywords:
Brain;
Echinococcosis;
Magnetic resonance spectroscopy;
Neoplasm metastasis
- From:
Chinese Journal of Medical Imaging Technology
2019;35(5):659-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the value of 1H-MRS in differential diagnosis of cerebral alveolar echinococcosis and brain metastases. Methods Twenty patients with alveolar echinococcosis and 20 patients with brain metastasis confirmed by postoperative pathology and clinical follow-up were collected, and routine and enhanced MR and 1H-MRS were performed, respectively. N-acetylaspartic acid (NAA), choline (Cho), creatine (Cr), lactic acid and lipids peaks (Lip+Lac) were observed in the parenchymal areas, edema areas and contralateral normal brain parenchyma of alveolar echinococcosis and brain metastases, and the ratios of Cho/Cr, Cho/NAA and (Lip+Lac)/Cr were calculated. Results: The values of Cho, Cho/Cr and Cho/NAA in parenchyma of alveolar echinococcosis were significantly lower than those of brain metastases, and Lip+Lac, (Lip+Lac)/Cr were significantly higher than those of brain metastases (all P<0.05). There was no significant difference in Cr, NAA of parenchyma, Cho, Cr, NAA, Lip+Lac, Cho/Cr, Cho/NAA, nor (Lip+Lac)/Cr of edema between alveolar echinococcosis and brain metastases (all P>0.05). The peaks of Cr, NAA in the parenchyma area and NAA in the edema area of alveolar echinococcosis were significantly lower than those in the contralateral normal brain, while Lip+Lac, Cho/Cr, Cho/NAA, (Lip+Lac)/Cr in the parenchyma and edema area were significantly higher than those in the contralateral normal brain parenchyma (all P<0.05). Parenchyma area Cho, Lip+ Lac peak, Cho/Cr, Cho/NAA, (Lip+Lac)/Cr and edema area Cho/NAA, (Lip+Lac)/Cr were significantly higher than those in the contralateral normal brain parenchyma, while NAA peak in the parenchyma was lower than that in the contralateral normal brain parenchyma (all P<0.05). Conclusion: 1H-MRS technique can display characteristics of tissue metabolism in the lesions and surrounding edema areas of alveolar echinococcosis and brain metastases, and provide objective basis for differential diagnosis.
