CEUS parameters in evaluation of muscle viability after ischemia-reperfusion in rabbit skeletal muscles
10.13929/j.1003-3289.201809094
- Author:
Weilin ZHANG
1
Author Information
1. Department of Ultrasonography, the People's Hospital of Deyang City
- Publication Type:Journal Article
- Keywords:
Contrast media;
Ischemia;
Muscle;
Reperfusion injury;
Skeletal;
Ultrasonography
- From:
Chinese Journal of Medical Imaging Technology
2019;35(5):646-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the feasibility of CEUS parameters in evaluation of muscle viability after ischemia-reperfusion in rabbit skeletal muscles. Methods Ischemia-reperfusion injury models of skeletal muscles (SMIRI) were established in rabbits. According to the "4C" sign of muscles in the most severely damaged area, the rabbits were then divided into muscle vitality group (n=10) and non-muscle vitality group (n=8). CEUS parameters of the most severely damaged area of the affected leg were compared between 2 groups before modeling (T0) and immediately (T1), 1 h (T2), 2 h (T3), 4 h (T4) after the rubber rings were removed. ROC curves were used to evaluate the diagnostic efficiency of CEUS parameters on viability of skeletal muscles after ischemia-reperfusion. Results: Absolute peak intensity (API) of T1 and T4 in muscle vitality group was higher than those in no-muscle vitality group (both P<0.05), there were no significant differences in other indexes between 2 groups at each time point (all P>0.05). ROC curves results showed that the sensitivity and specificity of API on T1 (cut-off value 6.93 dB) for evaluating muscle viability after ischemia-reperfusion of skeletal muscles was 100% and 60%, AUC was 0.85 (95%CI [0.67, 1.00], P<0.05), while API on T4 (cut-off value 4.25 dB) were 100% and 70%, AUC was 0.89 (95%CI [0.75,1.00], P<0.05), respectively. Conclusion: CEUS parameters can reflect muscle viability after ischemia-reperfusion of skeletal muscles, and API can be used as an evaluation index in ischemia-reperfusion injury rabbit models.
