Amide proton transfer weighted imaging evaluation on isocitrate dehydrogenase mutation status in patients with high-grade gliomas
10.13929/j.1003-3289.201810156
- Author:
Yonglu CHEN
1
Author Information
1. Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Science
- Publication Type:Journal Article
- Keywords:
Amide proton transfer weighted imaging;
Glioma;
Isocitrate dehydrogenase;
Mutation
- From:
Chinese Journal of Medical Imaging Technology
2019;35(6):823-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the value of amide proton transfer weighted (APTw) imaging in predicting isocitrate dehydrogenase (IDH) wild type and IDH mutant of high-grade gliomas. Methods: Twenty-five patients with pathologically confirmed high-grade gliomas were enrolled. All patients underwent preoperative MR scanning, including routine sequences, T1WI enhancement and APTw scanning. According to the pathology, the patients were divided into IDH wild type group and IDH mutant group. ROIs were placed on FLAIR images of all tumor layers to select the solid components of the tumor, and APT values of each layer were obtained to get the mean value. Differences of APT values were analyzed between groups using independent sample t test, and ROC curve analysis was performed to evaluate the diagnostic efficacy of APT values in assessing the gene status of IDH. Results: Among 25 patients of high-grade gliomas, 9 cases were IDH mutant and 16 cases were IDH wild type. APT value of IDH wild type group ([3.21±0.82]%) was significantly higher than that of IDH mutant group ([2.23±0.72]%; t=2.89, P<0.05), and the AUC was 0.84 (P<0.05). The sensitivity and specificity of IDH wild type diagnosis was 93.8% and 66.7%, respectively. Conclusion: APTw imaging can be used to predict gene status of IDH in high-grade gliomas.
