Feasibility of bone mineral density of T12 measured with quantitative CT for replacing abnormal lumbar vertebrae for diagnosis of osteoporosis
10.13929/j.1003-3289.201901102
- VernacularTitle: 定量CT测量T12骨密度替代病变腰椎用于骨质疏松诊断的可行性
- Author:
Yaling PAN
1
Author Information
1. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Bone density;
Lumbar vertebra;
Osteoporosis;
Thoracic vertebra;
Tomography, X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2019;35(7):1086-1090
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the feasibility of bone mineral density (BMD) of T12 for replacing abnormal L1 or L2 for diagnosis of osteoporosis during lung cancer screening with low-dose CT and bone mineral density examination with quantitative CT. Methods: Totally 1 298 healthy individuals who underwent lung cancer screening with low-dose CT and BMD examination with quantitative CT were enrolled. BMD of T12 to L2 vertebrae were measured, and the calibrated BMD of T12 was calculated and recorded as T12*. Taking L1+L2 as diagnostic criteria, the consistencies in bone mass assessment and the differences in diagnosis of osteoporosis among vertebral combinations of T12+L1, T12+L2, T12*+L1, T12*+L2 and L1+L2 were analyzed, respectively. Results: There were good consistencies between vertebral combinations and L1+L2 in bone mass assessment (all Kappa>0.75, all P<0.05). The specificities of vertebral combinations in osteoporosis diagnosis were all >98%. The sensitivities of T12+L1 and T12+L2 in osteoporosis diagnosis were 73.33% (143/195) and 77.95% (152/195), respectively, whereas of T12*+L1 and T12*+L2 in osteoporosis diagnosis were 83.08% (162/195) and 90.26% (176/195), respectively. Conclusion: BMD of T12 for replacing abnormal L1 or L2 during quantitative CT can reduce the sensitivity in diagnosis of osteoporosis, therefore BMD of T12 should be calibrated in measurement.
