18F-FDG PET/CT in prognostic evaluation of patients with lung cancer
10.13929/j.1003-3289.201810143
- Author:
Jing WANG
1
Author Information
1. Department of Nuclear Medicine, Ningxia Hui Autonomous Region People's Hospital
- Publication Type:Journal Article
- Keywords:
Fluorodeoxyglucose F 18;
Lung neoplasms;
Positron-emission tomography;
Prognosis
- From:
Chinese Journal of Medical Imaging Technology
2019;35(7):1028-1032
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the prognostic value of 18F-FDG PET/CT in patients with lung cancer. Methods: 18F-FDG PET/CT data and clinical data of 109 patients with lung cancer were retrospectively analyzed. The maximum standard value (SUVmax) of the lesion was measured, and the ratio of SUVmax to the largest tumor diameter (SUVmax/D) was calculated. Kaplan-Merier method was used to draw the survival curve, and COX univariate and multivariate regression models were used to analyze the impact factors of progression-free survival (PFS) and overall survival (OS) in patients with lung cancer. Results: SUVmax of all 109 patients with lung cancer was 1.50-34.90, median SUVmax was 7.90, SUVmax/D was 1.88-6.86 cm-1, median SUVmax/D was 1.90 cm-1, median OS was 22 months, and median PFS was 19 months. Univariate COX regression analysis showed that SUVmax, clinical staging and SUVmax/D were the impact factors for PFS (all P<0.05), while SUVmax, clinical staging and the largest tumor diameter were the impact factors for OS (all P<0.01). Multivariate COX regression analysis showed that SUVmax and clinical stage were independent predictors of PFS and OS of patients with lung cancer (all P<0.01). Conclusion: SUVmax and SUVmax/D of tumors have predictive value for prognosis of patients with lung cancer, and SUVmax may be an independent predictor of survival.
