Immunological Activities of Korean Mistletoe Extract ( Viscum album coloratum ; KM - 110 ).
- Author:
Jong Bae KIM
;
Taek Joon YOON
;
Yung Choon YOO
;
Tae Bong KANG
;
Myoung Sool DO
;
Ichiro AZUMA
- Publication Type:Original Article
- Keywords:
Viscum album coloratum;
Macrophage;
Tumor vaccine;
Adjuvant
- MeSH:
Animals;
Interferon-gamma;
Interleukin-1;
Lymphocytes;
Macrophages;
Macrophages, Peritoneal;
Mice;
Mistletoe*;
Mitogens;
Tumor Necrosis Factor-alpha;
Viscum album*;
Viscum*
- From:Korean Journal of Immunology
1997;19(4):571-582
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Immunological effect of the extract (KM-110) from Korean mistletoe (Viscum album coloratum) was examined. Lymphocytes obtained from KM-110-administrated mice showed increased responsiveness to mitogens, concanavalin-A (Con.A) and lipopolysaccharide (LPS). In order to study cytokine induct ability of the KM-110, macrophages from the Balb/c mice were cultivated in the medium containing the extract. the macrophages were shown to induce secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin 1 and 6 (IL-1, IL-6) and interferon-gamma (INF-gamma). We then tested antitumor activity of the macrophages activated by the KM-110. Peritoneal macrophages harvested from the KM110-treated Balb/c mice exhibited cytotoxicity against the syngeneic 3LL carcinoma cells. ...continue...
