Correlation of hippocampal MRS metabolites and cognitive function in patients with obstructive sleep apnea hypopnea syndrome
10.13929/j.1003-3289.201811134
- Author:
Wenwen ZHANG
1
Author Information
1. Department of Radiology, Gansu Provincial Hospital
- Publication Type:Journal Article
- Keywords:
Cognitive function;
Hippocampus;
Magnetic resonance spectroscopy;
Sleep apnea, obstructive
- From:
Chinese Journal of Medical Imaging Technology
2019;35(8):1175-1179
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correlation of hippocampal MRS metabolites and neurocognitive function in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: Single voxel proton MRS was performed on 31 patients with OSAHS (OSAHS group) and 28 healthy volunteers (control group).NAA, Cho and Cr peak in bilateral hippocampus were detected, and NAA/Cr, Cho/Cr and NAA/Cho were calculated. Montreal cognitive assessment scale (MoCA) and simple intelligent state scale (MMSE) were used to assess cognitive function, then to analyze the correlation of NAA/Cr, Cho/Cr, NAA/Cho and MoCA, MMSE scores in bilateral hippocampus. Results: Cho/Cr in bilateral hippocampus were higher in OSAHS group than in control group, while NAA/Cho in OSAHS group were lower than in control group (all P<0.05). There was no significant difference of NAA/Cr between OSAHS group and control group in bilateral hippocampus (all P>0.05). Cho/Cr in bilateral hippocampus of OSAHS patients were negatively correlated with MoCA and MMSE scores (all P<0.05), while NAA/Cho were positively correlated with MMSE scores (all P<0.05). Conclusion: MRS metabolites of bilateral hippocampus in OSAHS patients are correlated with cognitive function, which can be used as neuroimaging markers for cognitive impairment in OSAHS patients.
