Shear wave elastography in observation on tibial nerve changes in patients with diabetic peripheral neuropathy
10.13929/j.1003-3289.201902015
- Author:
Wei ZHAO
1
Author Information
1. Department of Ultrasound, Beijing Chao-yang Hospital, Capital Medical University
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Diabetic neuropathies;
Ultrasonography
- From:
Chinese Journal of Medical Imaging Technology
2019;35(8):1142-1146
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the value of shear wave elastography (SWE) in evaluating changes of tibial nerve in patients with diabetic peripheral neuropathy (DPN). Methods: Thirty patients of tpye 2 diabetes mellitus with DPN (DPN [+] group), 30 patients of type 2 diabetes mellitus without DPN (DPN [-] group) and 30 healthy control subjects (control group) were selected. The cross-sectional area (CSA) and mean nerve stiffness (Emean) of the tibial nerve in 3 groups were measured and compared with two-dimensional ultrasound and SWE. The correlation of pain visual analogue scale (VAS) with Emean in DPN (+) group as well as with tibial nerve CSA and motor nerve conduction velocity (MCV) in patients with type 2 diabetes mellitus were analyzed. ROC curve for Emean in diagnosis of DPN was drawn. Results: The overall differences of tibial nerve CSA and Emean among the 3 groups were statistically significant, and the pair-wise differences were also statistically significant (all P<0.01). There was positive correlation between CSA and Emean (r=0.64, P<0.05) and negative correlation between MCV and Emean (r=-0.70, P<0.05) in patients with type 2 diabetes mellitus. There was also positive correlation between VAS and Emean (r=0.82, P<0.05) in DPN (+) group. The cutoff value of the tibial nerve Emean for diagnosis of DPN was 47.4 kPa, with sensitivity of 94.2% and specificity of 80.0%. Conclusion: The tibial nerve stiffness increases in patients with type 2 diabetes. Elastic modulus can be used as a reference index for diagnosis of DPN.
