Quantitative analysis of T2 mapping in evaluating pathological features of cervical cancer
10.13929/j.1003-3289.201903113
- Author:
Shujian LI
1
Author Information
1. Department of MR, The First Affiliated Hospital of Zhengzhou University
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Pathology;
Uterine cervical neoplasms
- From:
Chinese Journal of Medical Imaging Technology
2019;35(9):1365-1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the quantitative analysis value of T2 mapping in the evaluation of pathological type, tumor grade and lymphovascular space invasion (LVSI) of cervical cancer. Methods: Totally 57 patients with pathologically proven cervical cancer underwent conventional MRI, DWI and T2 mapping before therapy. T2 and ADC values were obtained and compared between tumor and normal tissue (myometrium), squamous cell carcinomas and adenocarcinomas, well/moderately differentiated tumor and poorly differentiated tumor, LVSI-positive and LVSI-negative cervical cancer, respectively. ROC curve was constructed to evaluate diagnostic performances. Results: T2 and ADC values showed significant differences between cervical cancer and normal tissue (both P<0.001). No significant difference was observed in T2 and ADC values between squamous cell carcinomas and adenocarcinomas (both P>0.05). Compared to well/moderately differentiated tumors, poorly differentiated tumors showed decreased T2 and ADC values (both P <0.05). T2 values were significantly lower in LVSI-positive than in LVSI-negative cervical cancer (P=0.002), while ADC values were not significantly different (P=0.675). The AUC of T2 and ADC values for distinguishing tumor grade were 0.709 and 0.747, respectively. The AUC of T2 value in discriminating the presence of LVSI was 0.856. Conclusion: Quantitative T2 mapping can putatively differentiate the grade of cervical cancer. Moreover, quantitative T2 value exhibits better than ADC for discriminating the presence of LVSI.
