Effects of Propolis and Caffeic Acid Phenethyl Ester on Tumorigenesis, Pulmonary Metastases, and Activities of Splenocytes and Macrophages in Mice.
- Author:
Yo Han SONG
;
Hong Yeol HUH
;
Chin Soo KIM
;
Kang Ju KIM
- Publication Type:Original Article
- Keywords:
Propolis;
Tumorigenesis;
Immune function
- MeSH:
Animals;
Bees;
Carcinogenesis*;
Ethanol;
Honey;
Macrophages*;
Medicine, Traditional;
Mice*;
Mice, Inbred ICR;
Neoplasm Metastasis*;
Propolis*
- From:Korean Journal of Immunology
1997;19(4):617-628
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The propolis, honey bee hive product, is a folk medicine for treating various ailrnents and caffeic acid phenethyl ester (CAPE) is an extract of propolis. The purpose of this study was to examine the effects of ethanol extracted propolis (EEP) or CAPE on the tumorigenesis, pulmonary metastases, and proliferation and activity of splenocytes and macrophages in ICR mice. EEP at 0.2, 2 or 20mg/ml applied topically on the back of each mice 30 minutes before application of 7,12-dimethylbenz (a)anthracene and 12-0-tetradecanoylphorbol-13-acetate inhibited the number of tumors per mouse by 61, 75 or 100%, respectively. ...continue...
