Relationship of 18F-FDG PET/CT metabolic indexes and clinicopathological factors of colorectal adenocarcinoma
10.13929/j.1003-3289.201903003
- Author:
Jin ZHOU
1
Author Information
1. PET/CT Center, Shuyang Affiliated Hospital of Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Fluorodeoxyglucose F 18;
Positron-emission tomography;
Tomography;
X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2019;35(10):1517-1521
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the correlation of 18F-FDG PET/CT imaging metabolic indexes and clinicopathological factors of primary colorectal adenocarcinoma. Methods: Clinical data of 52 patients with colorectal adenocarcinoma confirmed by operation and pathology were retrospectively analyzed. All patients underwent 18F-FDG PET/CT imaging, and the maximum diameter, maximum standard uptake value (SUVmax), mean standard uptake value(SUVmean) and metabolic volume (MTV) of the primary tumors were recorded, and the total lesion glycolysis (TLG) was calculated. The patients were grouped according to the largest diameter, T stage, N stage and cell differentiation degree of the primary tumor respectively, and the differences of the above parameters were compared, and the correlations of the above parameters and clinicopathological features were analyzed. Results: SUVmax, SUVmean, MTV and TLG of 52 patients with colorectal adenocarcinoma were 13.38±7.34, 7.75±3.94, (15.83±11.18)cm3 and 103.15(45.28,140.23)g, respectively. There were significant differences in metabolic indexes of the maximum diameter groups (all P<0.05). There was no significant difference in SUVmax and SUVmean among different T-stage groups (both P>0.05), while there were significant differences in MTV and TLG among different T-stage groups (both P<0.05). There was no significant difference in the metabolic indexes of colorectal adenocarcinoma among different N stages and cell differentiation groups (all P>0.05). There were positive correlations of SUVmax, SUVmean with the maximum diameter of the primary tumor (both P<0.05), while there was no obvious correlation with T stage, N stage and cell differentiation degrees (all P>0.05). MTV and TLG were positively correlated with the maximum diameter and T stage of the primary tumor (all P<0.05), but not correlated with N stage nor cell differentiation degrees (all P>0.05). Conclusion: MTV and TLG can reflect the pathological factors of colorectal adenocarcinoma in some degree, and have higher evaluation value than SUVmax and SUVmean.
