Correlation between ADC value of cerebral nuclei and age in different aged Alzheimer disease patients
10.13929/j.1003-3289.201812155
- Author:
Cong ZHANG
1
Author Information
1. Department of Radiology, Shengjing Hospital of China Medical University
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Apparent diffusion coefficient;
Diffusion magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2019;35(10):1461-1466
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correlation between ADC value of cerebral nuclei and age in patients with Alzheimer disease (AD) with different ages. Methods: Thirty AD patients (AD group) and 30 matched volunteers (control group) were enrolled and divided into 6 subgroups according to age (55-59 years old [n=3], 60-64 years old [n=4], 65-70 years old [n=9], 71-74 years old [n=5], 75-80 years old [n=6], >80 years old [n=3]). ADC values of left and right hippocampus, red nucleus, caudate nucleus, amygdala and putamen were measured. The paired t-test, independent sample t-test, one-way ANOVA and Pearson correlation analysis were performed. Results: There were significant differences of ADC values between left and right red nucleus in AD group (P=0.022), also of ADC values in right hippocampus, bilateral caudate nucleus and right caudate nucleus in different age subgroups of AD group (all P<0.05). There were significant differences of ADC values in bilateral hippocampus, putamen and caudate nucleus among different subgroups of AD group and control group (all P<0.05). Positive correlations of age and right hippocampus (r=0.615, P<0.001), right putamen (r=0.653, P=0.001) and bilateral caudate nucleus (left: r=0.397, P=0.030; right: r=0.429, P=0.020) were found in AD group. Conclusion: ADC values in bilateral hippocampus, putamen and caudate nucleus of AD patients increase with age. ADC values can provide references for clinical prediction and early diagnosis of neurodegenerative lesions in bilateral hippocampus, putamen and caudate nucleus of AD brain.
