Correlation between gestational age and ADC value in normal fetal brain region detected using DWI with b value as 1 000 s/mm2
10.13929/j.1003-3289.201905187
- Author:
Mengying XU
1
Author Information
1. Graduate School, Ningxia Medical University
- Publication Type:Journal Article
- Keywords:
Apparent diffusion coefficient;
B value;
Brain;
Diffusion magnetic resonance imaging;
Fetus;
Gestational age
- From:
Chinese Journal of Medical Imaging Technology
2019;35(11):1707-1711
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between ADC value of normal fetal brain region obtained on ADC image generated with DWI of b value as 1000 s/mm2 and gestational age. Methods: A retrospective analysis of 106 pregnant women who underwent routine MR and DWI examinations due to suspected fetal abnormalities with prenatal ultrasonography was performed. Among them, 28 pregnant women were in the second trimester (13-27 weeks) and 78 pregnant women were in the third trimester (≥28 weeks). All fetuses were confirmed as normal neurodevelopment with prenatal routine MR and DWI examinations, as while as postnatal follow-up. DWI was performed with b value of 1000 s/mm2. ADC maps were generated based on DWI,and ADC values of frontal lobe, parietal lobe, temporal lobe, occipital lobe white matters, basal nucleus, thalamus, cerebellar hemisphere and pons were measured. The correlation between ADC values in different fetal brain regions and gestational age was analyzed using linear regression. Results: ADC values of different parts of normal fetal brain were in order from high to low: Parietal white matter ([1.84±0.08]mm2/s), occipital white matter ([1.82±0.08]mm2/s), frontal white matter ([1.77±0.03]mm2/s), temporal white matter ([1.70±0.13]mm2/s), cerebellar hemisphere ([1.41±0.10]mm2/s), basal ganglia ([1.40±0.13]mm2/s), thalamus ([1.35±0.04]mm2/s), pons ([1.27±0.08]mm2/s). Except for frontal white matter, ADC values of the rest of the normal fetal brain regions were negatively correlated with gestational age (all P<0.05). Conclusion: Most of ADC values in normal fetal brain different regions decreased with increasing gestational age, which can reflect the developmental process of fetal brain.
