Resting-state fMRI observation on impact of six months' Methadone maintenance treatment and protracted abstinence on brain function in Heroin dependents
10.13929/j.1003-3289.201907217
- Author:
Wei LIU
1
Author Information
1. Department of Radiology, Tangdu Hospital, Air Force militaryMedical University
- Publication Type:Journal Article
- Keywords:
Addiction;
Amplitude of low frequency fluctuation;
Heroin;
Methadone maintenance treatment;
Protracted abstinence
- From:
Chinese Journal of Medical Imaging Technology
2019;35(11):1638-1642
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of protracted abstinence (PA) and methadone maintenance treatment (MMT) on the brain function of heroin addicts for 6 months. Methods: Twenty-two heroin addicts with PA for 6 months intervention (PA group), 25 heroin addicts with MMT for 6 months intervention (MMT group), and 35 normal controls (control group) were recruited. The resting data were collected by fMRI. The low-frequency amplitude (ALFF) method was used to calculate the intensity of local brain spontaneous activity in the 3 groups. The differences in ALFF of the 3 groups were analyzed and compared. Results: There were significant differences in ALFF between the 3 groups in the right frontal medial, left medial frontal gyrus, left island leaf, left tongue lingual, right lingual gyrus and right auxiliary motion zone (all P<0.01). And ALFF of right frontal medial, left medial frontal gyrus, left tongue lingual, right lingual gyrus and right auxiliary motion in PA group were statistical different with those in MMT group (all P<0.01). The brain activity in the right frontal gyrus, the left medial frontal gyrus and the right supplementary motor in PA group were closer to the normal group (all P>0.05). Conclusion: After 6 months of intervention, there are still abnormalities in some brain regions between PA and MMT, but PA may be more conducive to brain function recovery in heroin addicts.
