From solitary bone plasmacytoma to multiple myeloma: Early predicting with 18F-FDG PET/CT
10.13929/j.1003-3289.201905116
- Author:
Meixin ZHAO
1
Author Information
1. Department of Nuclear Medicine, Peking University Third Hospital
- Publication Type:Journal Article
- Keywords:
Fluorodeoxyglucose F18;
Multiple myeloma;
Radionuclide imaging;
Solitary bone plasmacytoma
- From:
Chinese Journal of Medical Imaging Technology
2019;35(12):1861-1865
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the predictive value of 18F-FDG-PET/CT imaging and other clinicopathological factors for prognosis of solitary bone plasmacytoma (SBP) to multiple myeloma (MM). Methods: Twenty patients underwent 18F-FDG PET/CT. All patients were pathologically confirmed as SBP and followed-up. Taken progression to MM as a clinical outcome, the patients were divided into progressive group and non-progressive group. Immunoglobulin fixed electrophoresis, M protein, positive rate of free light chain in blood, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in PET/CT images were analyzed between the two groups. Results: Eight patients developed into MM (progressive group), whereas the other 12 patients did not (non-progressive group). MTV in progressive group was higher than that in non-progressive group (Z=-2.807, P=0.031). There was no significant difference of serum immunoglobulin electrophoresis, M protein, free light chain level, Ki67 positive rate of tumor cells, SUVmax nor TLG between the two groups (all P>0.05). Conclusion: High MTV level is a poor prognostic factor for the progression of SBP to MM. Patients with high MTV level may need more clinical attention and active intervention to delay progression of SBP to multiple myeloma as far as possible.
