Evaluation on CT perfusion imaging parameters and therapeutic effect of intravenous thrombolysis in patients with acute cerebral infarction
10.13929/j.1003-3289.201906154
- Author:
Ansheng GAO
1
Author Information
1. Department of Radiology, Zhumadian Central Hospital
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Perfusion imaging;
Plasminogen activator;
Thrombosis-related factor
- From:
Chinese Journal of Medical Imaging Technology
2019;35(12):1823-1827
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the therapeutic effect of recombinant plasminogen activator (rt-PA) in treatment of acute cerebral infarction using CT perfusion imaging (CTPI). Methods: Totally 100 patients with acute cerebral infarction within 6 h of onset were divided into observation group (presence of ischemic penumbra, n=56) or control group (without ischemic penumbra, n=44) according to CTPI. All patients were treated with rt-PA. After treatment, CTPI was used to evaluate perfusion in the infarcted area. Plasma thrombosteroid-related factor level was tested, and the improving of neurological deficits and activities of daily living were evaluated. Results: The cerebral blood volume (CBV) and cerebral blood flow (CBF) values in the infarct area of observation group significantly increased after treatment (all P<0.05), and the mean transition time (MTT) value was significantly lower (all P<0.05). After treatment, CBV and CBF values of observation group were significantly higher than those of control group (both P<0.05). The plasma thrombosteroid-related factor level decreased (P<0.05). NIHSS score and Barthel index (BI) score of observation group were significantly improved after treatment, also better than those of control group (both P<0.05). Conclusion: Under the guidance of CTPI, rt-PA intravenous thrombolysis can significantly improve the brain tissue perfusion in ischemic penumbra, reduce the level of thrombus-related factors and alleviate brain tissue damage and neurological deficits.
