Captopril renal scintigraphy in diagnosis of renovascular hypertension and the impact of plasma renin activity
10.13929/j.issn.1003-3289.2020.03.016
- Author:
Xiemei RUAN
1
Author Information
1. Department of Nuclear Medicine, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital
- Publication Type:Journal Article
- Keywords:
Captopril;
Hypertension, renal;
Radionuclide imaging;
Renin-angiotensin system
- From:
Chinese Journal of Medical Imaging Technology
2020;36(3):387-390
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the diagnostic efficiency of Captopril renal scintigraphy (CRS) for renovascular hypertension (RVH) and the impact of plasma renin activity (PRA). Methods: Plasma levels of PRA, angiotensin Ⅱ (AngⅡ) and aldosterone (ALD) in peripheral blood in orthostatic position and supine position of 35 RVH patients who underwent basic renal scintigraphy and CRS examination were retrospectively analyzed. According to CRS, the patients were divided into positive group and negative group. The levels of PRA, AngⅡ and ALD were analyzed. ROC curve was used to analyze PRA and obtain the minimum threshold. Results: There were 24 cases in positive group and 11 cases in negative group. The orthostatic position PRA in positive group was significantly higher than that in negative group (Z=3.11,P<0.001). The supine position PRA, supine and orthostatic position AngⅡ and ALD were not statistically different between two groups (all P>0.05). ROC curve analysis showed that the area under the curve was 0.84. When the threshold point of PRA was 2.47 ng/(ml·h), the sensitivity and specificity were 83.33% and 81.82%, respectively. Conclusion: Orthostatic position PRA is an important impact factor of diagnostic sensitivity of CRS for RVH. Combining with orthostatic position plasma PRA can improve the value of CRS for diagnosis and treatment of RVH.
