Assessing kidney injury of hyperuricemia patients with MR diffusion tensor imaging
10.13929/j.issn.1003-3289.2020.04.023
- VernacularTitle: MR扩散张量成像评估高尿酸血症患者肾损伤
- Author:
Zhongyuan CHENG
1
Author Information
1. Department of Medical Imaging Center, the First Affiliated Hospital of Jinan University
- Publication Type:Journal Article
- Keywords:
Diffusion tensor imaging;
Hyperuricemia;
Kidney injury;
Magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2020;36(4):574-578
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the feasibility of MR diffusion tensor imaging (DTI) in evaluating early renal function injury of hyperuricemia. Methods: Totally 23 male patients with asymptomatic hyperuricemia (AH group), 30 patients with gouty arthritis (GA group) and 23 healthy volunteers (HC group) were collected. Serum uric acid (SUA) and estimated glomerular filtration rate (eGFR) were recorded, and then routine MRI and DTI were performed. The differences of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values of renal cortex or medulla, SUA and eGFR of 3 groups were compared. The correlations of ADC and FA values of renal cortex or medulla with SUA and eGFR were analyzed, and the correlation of SUA and eGFR was analyzed. Results: SUA of HC group was lower than that of AH and GA group (both P<0.05), while eGFR of GA group was lower than that of HC group (P<0.05). FA values of renal cortex and medulla in AH group and GA group were lower than that of HC group (all P<0.05). The cortical ADC values in AH group and GA group and medullary ADC value in GA group were lower than that in HC group (all P<0.05). FA values of renal cortex and medulla (r=-0.41, -0.40), ADC values of renal cortex and medulla (r=-0.34, -0.28,) showed negative correlations with SUA (all P<0.05) but not with eGFR. Also, negative correlation of eGFR and SUA was found (r=-0.43, P<0.05). Conclusion: DTI can be used to evaluate early renal function injury caused by hyperuricemia. ADC and FA value of renal cortex and medulla of hyperuricemia patients are lower than that of normal people. ADC value and FA value of renal cortex or medulla are negatively correlated with SUA, while SUA is positively correlated with the degree of renal impairment.
