Evaluation on correlation of intra-renal arterial resistance index and abdominal aortic intima-media thickness in type 2 diabetic nephropathy with color Doppler ultrasonography
10.13929/j.issn.1003-3289.2020.05.023
- VernacularTitle: 彩色多普勒超声评价糖尿病肾病患者肾内动脉阻力指数与腹主动脉内-中膜厚度的相关性
- Author:
Fang LI
1
Author Information
1. Department of Diagnostic Ultrasound, the Second Hospital of Dalian Medical University
- Publication Type:Journal Article
- Keywords:
Aorta, abdominal;
Diabetic nephropathies;
Renal artery;
Ultrasonography, Doppler, color
- From:
Chinese Journal of Medical Imaging Technology
2020;36(5):738-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the correlation of intra-renal arterial resistance index (RI) and abdominal aortic intima-media thickness (AA-IMT) in type 2 diabetic nephropathy (DN) patients with color Doppler ultrasonography. Methods: Ninety-three patients with type 2 DN were enrolled, and 35 healthy volunteers were enrolled as control group (group A). DN patients were divided into 3 groups according to the level of glomerular filtration rate (GFR), i.e. group B (n=33)with GFR≥90 ml/(min•1.73 m2), group C (n=31) with 60 ml/(min•1.73 m2)≤GFR<90 ml/(min•1.73 m2) and group D (n=29) with GFR<60 ml/(min•1.73 m2). The intra-renal arterial RI and AA-IMT were obtained with color Doppler ultrasonography. Results: The values of RI and AA-IMT of group B, C, D were higher than those of group A (all P<0.05), while those of group C, D were higher than group B (all P<0.05), and RI and AA-IMT of group D were higher than those of group C (both P<0.05). RI was positively correlated with AA-IMT (r=0.90, P<0.01), glycosylated hemoglobin (r=0.58, P<0.01), glucose (r=0.66, P<0.01), total cholesterol (r=0.42, P<0.01), low density lipoprotein (r=0.03, P<0.01), creatinine (r=0.64, P<0.01), uric acid (r=0.54, P<0.01) and negatively correlative with estimated GFR (eGFR) (r=-0.84, P<0.01), respectively. Taken RI=0.70 as the cut-off point as an indicator of mild renal damage (GFR<90 ml/ [min•1.73 m2] )of DN patients, patients with RI above 0.70 had higher AA-IMT than those with RI lower values (P<0.05), and the sensibility was 84.1%, specificity was 92.9%. AA-IMT and eGFR were independent predictors of RI. Conclusion: The intra-renal arterial RI and AA-IMT in the patients of type 2 DN can be noninvasively obtained with color Doppler ultrasonography for evaluation on microvascular and macrovascular injuries of type 2 DN patients.