18F-FDG PET/CT metabolic parameters for prognosis of primary cervical cancer
10.13929/j.issn.1003-3289.2020.05.021
- VernacularTitle: 18F-FDG PET/CT代谢参数预测原发性宫颈癌预后
- Author:
Xing ZHOU
1
Author Information
1. Radiation Oncology Key Laboratory of Sichuan Province, PET, CT Centre, Sichuan Cancer Hospital
- Publication Type:Journal Article
- Keywords:
Cervix uteri;
Fluorodeoxyglucose F 18;
Positron-emission tomography;
Tomography, X-ray computed;
Uterine neoplasms
- From:
Chinese Journal of Medical Imaging Technology
2020;36(5):726-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the predictive value of metabolic parameters with different maximum standard intake value (SUVmax) threshold segmentations calculated from 18F-FDG PET/CT before concurrent chemoradiotherapy (CCRT) of cervical cancer. Methods: Totally 45 patients underwent 18F-FDG PET/CT before CCRT, and SUVmax, maximum standard intake value (MTV) and metabolic tumor volume (TLG) were recorded. MTV and TLG were automatically segmented using different percentage SUVmax threshold segmentations (10%-85%, increased by 5%). Receiver operating characteristic (ROC) curve analysis was performed in order to obtain the cut-off values of MTV and TLG. Kaplan-Meier method was used for survival analysis. Results: SUVmax, MTV10%, MTV75%-MTV85% and TLG75%-TLG85% were not significantly different (all P>0.05), whereas significant differences of MTV15%-MTV70% and TLG10%-TLG70%were found between 2 groups (all P<0.05). 40%SUVmax had the strongest prediction capability for prognosis. Based on ROC curve analysis, the cut-off value of MTV40% was 21.09, with sensitivity of 78.60%, specificity of 87.10% and AUC of 0.823, while the cut-off value of TLG40% was 136.71, with sensitivity of 78.60%, specificity of 77.40% and AUC of 0.788. Conclusion: MTV40% and TLG40% calculated from 18F-FDG PET/CT can be taken as prognostic indicators for cervical cancer after CCRT.
