Acute kidney injury induced by iodine contrast agent in a rabbit model using intravoxel incoherent motion and blood oxygen level-dependent imaging techniques
10.13929/j.issn.1003-3289.2020.05.001
- VernacularTitle: 体素内不相干运动扩散成像及血氧水平依赖成像评估碘对比剂致兔急性肾损伤
- Author:
Rongjia WANG
1
Author Information
1. Department of Radiology, the First Hospital of China Medical University
- Publication Type:Journal Article
- Keywords:
Acute kidney injury;
Blood oxygenation level-dependent;
Contrast media;
Intravoxel incoherent motion;
Iodine;
Rabbits
- From:
Chinese Journal of Medical Imaging Technology
2020;36(5):641-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the impact of non-ionic dimeric isotonic iodine contrast agent on rabbit kidneys using intravoxel incoherent motion (IVIM)-DWI and blood oxygen level-dependent (BOLD) imaging. Methods: Totally 25 male New Zealand rabbits were randomly equally divided into 5 groups (each n=5). IVIM-DWI and BOLD scanning and blood collection were performed in four experimental groups (1, 24, 48, 72 h group) 1, 24, 48,72 h after injection of iodixanol, respectively, also in base-line group after injection of equal amount of saline. The rabbits were killed immediately after MRI,and the kidneys were taken for histopathological analysis. Results: Compared with base-line group, both cortex and medulla of kidneys showed decreased ADC, D and f values and the lowest D* value, as well as increased R2* in 1 h group. The lowest ADC, D and f values, the highest R2* and increased D* value of both cortex and medulla were observed in 24 h group. In 72 h group, R2* value of both cortex and medulla were still lower than baseline (all P<0.05), and D* value basically returned to baseline, while f and D values of medulla were still statistically different with respect to baseline (all P<0.05). Meanwhile, different degrees of glomerular and tubular damage were observed in the pathological sections. The serum creatinine and blood urea nitrogen in 48 h group and 72 h group were higher than those in base-line group (all P<0.05). The expression of hypoxia inducible factor-1α and heme oxygenase-1 increased in 1 h group and up to peak in 24 h group. Conclusion: Combining IVIM-DWI with BOLD can effectively evaluate rabbit renal pathophysiologic changes associated with contrast-induced acute kidney injury.
