The Clinical Significance of Expression of Bcl-2 and CD-44 molecules in Cervical Cancer and Its Correlation with Known Prognostic Factors.
- Author:
Dong Kyu KIM
;
Hyun Yong JUNG
;
Young Tae KIM
;
Byung Seok LEE
;
Kyung SEO
;
Yoon Ho LEE
;
Kook LEE
;
Jae Wook KIM
;
Nam Hoon CHO
- Publication Type:Original Article
- Keywords:
Bcl-2 gene;
CD-44 molecules;
spliced variant form V6;
cervical cancer;
CD-44
- MeSH:
Carcinogenesis;
Genes, bcl-2;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Prognosis;
Retrospective Studies;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
1999;42(11):2531-2535
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The study was designed to investigate the expression of Bcl-2 and CD-44 molecules in cervical cancer and compare the results with known clinical prognostic factors, and lastly to define the roles of Bcl-2 and CD-44 molecules in tumorigenesis and metastasis of cervical cancer. METHODS: A total of 85 patients were enrolled in this study and retrospective analysis of prognostic factors were compared with immunohistochemical staining of Bcl-2 and CD-44. RESULTS: The expression of Bcl-2 was relatively even when we compared with stage, cell types, grade and lymph node metastasis. And the CD-44 spliced variant form V6 expression was significantly strong in higher stage and positive lymph node metastasis but cell types and grade of tumor does not correlated with status of CD-44 expression. CONCLUSION: Bcl-2 expression in cervical cancer does not correlate with clinical prognostic factors, but CD-44 spliced variant V6 form does correlated with poor prognostic factors. CD-44 may play a role in the process of the tumor metastasis and poor prognosis.
