Ultrafast pulse wave velocity technique in assessment of impacts of vitamin D deficiency on early carotid elasticity in patients with type 2 diabetes
10.13929/j.issn.1003-3289.2020.06.008
- VernacularTitle: 极速脉搏波速度技术评价维生素D缺乏对2型糖尿病患者早期颈动脉弹性功能的影响
- Author:
Anning LIU
1
Author Information
1. Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University
- Publication Type:Journal Article
- Keywords:
Carotid arteries;
Diabetes mellitus, type 2;
Elasticity;
Ultrafast pulse wave velocity;
Vitamin D deficiency
- From:
Chinese Journal of Medical Imaging Technology
2020;36(6):839-843
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the impacts of vitamin D deficiency on early carotid elasticity in patients with type 2 diabetes mellitus (T2DM) using ultrafast pulse wave velocity (UFPWV) technique. Methods: A total of 92 patients with T2DM were enrolled (T2DM group) and divided into vitamin D deficiency subgroup and vitamin D non-deficiency subgroup according to the level of 25-hydroxyvitamin D3 (25[OH]D3), while 1 544 normal adults were taken as controls(control group). UFPWV technique was used to measure carotid elasticity parameters, including pulse wave velocity at the beginning of systole (PWV-BS) and the end of systole (PWV-ES), and clinical data and laboratory indicators of both groups were collected. Then statistical analysis of the above data was performed. Results: ①Among T2DM group, the levels of body mass index (BMI), fasting blood glucose (FPG), systolic blood pressure, diastolic blood pressure, total cholesterol (TC), triglyceride, PWV-BS and PWV-ES of vitamin D deficiency subgroup were higher than those of non-deficient subgroup (all P<0.05), while the level of high density lipoprotein cholesterol (HDL-C) was lower than that of the vitamin D non-deficient subgroup (P<0.05). ②Pearson correlation analysis showed that PWV-BS and PWV-ES were positively correlated with age, BMI, FPG, systolic blood pressure, diastolic blood pressure and TC (all P<0.05) but negatively correlated with 25(OH)D3 and HDL-C (P<0.05). ③Multivariate linear stepwise regression analysis showed that FPG, systolic blood pressure, age and TC were risk factors for PWV-BS and PWV-ES (all P<0.05), whereas 25(OH)D3 was a protective factor for PWV-ES (P<0.05). Conclusion: PWV-BS and PWV-ES values in T2DM patients with vitamin D deficiency significantly elevated. Vitamin D may be a protective factor for carotid elasticity in patients with T2DM. Monitoring vitamins level in T2DM patients is promptly supplemented. Vitamin D may delay the development of T2DM complications.
