Virtual touch tissue imaging quantification combined with CEUS in differential diagnosis of benign and malignant TI-RADS 4 thyroid nodules
10.13929/j.issn.1003-3289.2020.06.006
- VernacularTitle: 声触诊组织量化成像联合超声造影鉴别诊断TI-RADS 4类良恶性甲状腺结节
- Author:
Jin TONG
1
Author Information
1. Department of Ultrasound, First Affiliated Hospital, School of Medicine, Shihezi University
- Publication Type:Journal Article
- Keywords:
Thyroid nodule;
Ultrasonography;
Virtual touch tissue imaging quantification
- From:
Chinese Journal of Medical Imaging Technology
2020;36(6):828-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the value of virtual touch tissue imaging quantification (VTIQ) combined with contrast-enhanced ultrasound (CEUS) in differential diagnosis of benign and malignant TI-RADS 4 thyroid nodules. Methods: Totally 86 patients underwent surgical operation and were pathologically diagnosed were selected, including 45 benign(benign group) and 53 malignant ( malignant group) TI-RADS 4 thyroid nodules. VTIQ and CEUS were performed before operation, and the maximal shear wave velocity (SWVmax), minimum shear wave velocity (SWVmin), mean shear wave velocity (SWVmean) as well as the ratio of lesion SWVmax to the surrounding normal tissue shear wave velocity (SWVratio) and CEUS characteristics were obtained and recorded. Then Logistic regression model of VTIQ combined with CEUS was established, the diagnostic effectiveness of VTIQ, CEUS and the combination of VTIQ and CEUS regression models of benign and malignant TI-RADS 4 thyroid nodules were compared using area under the curve (AUC). Results: SWVmax, SWVmin, SWVmean and SWVratio in malignant group were all higher than those in benign group (all P<0.05). For CEUS, the enhancement degree, enhancement uniformity, enhancement mode, ring enhancement and regression mode were all significantly different between groups (all P<0.05). SWVmean >2.96 m/s and low enhancement were important indexes for malignant nodules (P<0.05). AUC of SWVmean, CEUS and Logistic regression model were 0.862, 0.835 and 0.933, respectively. Conclusion: VTIQ and CEUS have good differential diagnostic ability for benign and malignant TI-RADS 4 thyroid nodules. Combination of VTIQ and CEUS can significantly improve the diagnostic effectiveness.