Correlation between permeability of blood-brain barrier and total MRI burden in patients with cerebral small vessel disease
10.13929/j.issn.1003-3289.2020.09.007
- VernacularTitle: 脑小血管疾病血脑屏障通透性与MRI总负担的相关性
- Author:
Man LI
1
Author Information
1. Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University
- Publication Type:Journal Article
- Keywords:
Blood-brain barrier;
Cerebral small vessel diseases;
Magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2020;36(9):1303-1308
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between permeability of blood-brain barrier (BBB) and total MRI cerebral small vessel disease (CSVD) burden with dynamic contrast-enhanced MRI (DCE-MRI). Methods: A total of 104 patients were evaluated using 5 points CSVD imaging burden scale, including lacunes, white matter hyperintensities (WMH), cerebral microbleeds (CMB), enlarged perivascular spaces (EPVS) and brain atrophy (BA). The patients were then were divided into 6 groups according to the result of total CSVD burden score (0-5), i. e. CSVD0 group, 1 group, 2 group, 3 group, 4 group and CSVD5 group. DCE-MRI were performed, and Patlak pharmacokinetic model was used to quantify BBB permeability in WMH, normal-appearing white matter (NAWM), cortical gray matter (CGM) and deep gray matter (DGM). Results: Finally 99 patients were included. After adjusting for age, gender and vascular risk factors, the total imaging burden of CSVD was positively correlated with leakage rate (Ktrans) and area under the curve (AUC) in 4 regions of NAWM, WMH, CGM and DGM (all P<0.05). In NAWM, CGM and DGM regions, the total imaging burden of CSVD was negatively correlated with fractional blood plasma volume (Vp) (all P<0.05). Conclusion: Increased BBB permeability associated with total MRI CSVD burden, suggesting that damaged BBB may be a crucial contributor to the pathogenesis of CSVD.
