A case of Zollinger-Ellison syndrome with MEN-1.
- Author:
Yun Ho KONG
1
;
Young Don KIM
;
Koon Hee HAN
;
Se Hyung LEE
;
Woo Jin JUNG
;
Hyuk Jai JANG
;
Gab Jin CHEON
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea. gi@gnah.co.kr
- Publication Type:Case Report
- Keywords:
Zollinger-Ellison syndrome;
Gastrinoma;
Multiple endocrine neoplasia (MEN-1)
- MeSH:
Abdominal Pain;
Diarrhea;
Dilatation;
Duodenum;
Esophageal Stenosis;
Esophagitis, Peptic;
Fasting;
Gastric Acid;
Gastrinoma;
Gastrins;
Gastroesophageal Reflux;
Humans;
Middle Aged;
Multiple Endocrine Neoplasia Type 1;
Parathyroid Neoplasms;
Proton Pump Inhibitors;
Receptors, Somatostatin;
Stents;
Ulcer;
Zollinger-Ellison Syndrome
- From:Korean Journal of Medicine
2010;79(3):289-294
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Zollinger-Ellison syndrome (ZES) is a clinical syndrome caused by excessive gastric acid secretion by gastrinoma, characteristically causing peptic disease and/or gastroesophageal reflux disease. Approximately one third of patients with gastrinoma have multiple endocrine neoplasia type 1 (MEN-1). A 56-year-old man was admitted for abdominal pain and diarrhea lasting for 2 weeks. The endoscopic findings revealed severe reflux esophagitis and multiple ulcers at the bulb and second portion of the duodenum. He was diagnosed as ZES based on typical clinical features such as markedly elevated fasting gastrin level (> or =1,263 pg/mL) and findings from a CT scan and somatostatin receptor scan. Pathologic findings after the operation revealed malignant gastrinoma. He was confirmed to have parathyroid adenoma and MEN-1. Despite antisecretory therapy with proton pump inhibitors, an esophageal stricture developed, and we performed esophageal balloon dilatation and stent insertion.
