The clinical study of 37 pregnancy women with aplastic anemia.
- Author:
Keun Ho LEE
;
Jong Kun LEE
;
Jin Hee YOO
;
Jee Hyun LEE
;
Hyeong Kwon JO
;
Ji Young LEE
;
Seung Jo KIM
;
Soo Pyung KIM
- Publication Type:Original Article
- Keywords:
Pregnancy;
Aplastic anemia
- MeSH:
Anemia, Aplastic*;
Birth Weight;
Blood Platelets;
Diagnosis;
Eclampsia;
Female;
Hematocrit;
Humans;
Medical Records;
Obstetric Labor, Premature;
Obstetrics;
Parity;
Pre-Eclampsia;
Pregnancy*;
Reticulocytes;
Risk Factors
- From:Korean Journal of Obstetrics and Gynecology
1999;42(11):2536-2541
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Objectives: To determine whether the clinical aspect of aplastic anemia is influenced by pregnancy. METHODS: We reviewed 37 cases of pregnant aplastic anemia patients during Jan. 1989 to Dec. 1998, and examined age, parity, progress of pregnancy, termination methods, obstetrics & neonatal complications, hematologic change, and treatment modality by medical records. RESULTS: According to onset of disease, patients were divided into pre-pregnant diagnosed group(n=12) and during-pregnancy diagnosed group(n=25). Mean age of diagnosis was 29.4yr, 89.2% were nulliparous, and 51.4% were severe aplastic anemic patients. All patients underwent 50 pregnancy. Mean gestational period was 37wks, birth weight was 2569gram, and, except in 7 cases of abortion, 43 cases were delivered transvaginally or transabdominally(51.2% vs. 48.8%). Preeclampsia, eclampsia, preterm labor, restricted growth, and distress were complicated and decreased hemoglobin, hematocrit, reticulocyte, platelet were reversed after termination in pregnancy associated group. Treatment modality during pregnancy included transfusion, steroid, anti-lymphocytic globulin, anti-thymocytic globulin and IVGV, and remission rate was 45.5% in pregnancy associated group. CONCLUSION: We concluded that pregnancy is associated with aplastic anemia as a high risk factor, and intensive treatment is needed.
