Evaluation on prognosis of soft tissue sarcomas after surgery with preoperative MRI
10.13929/j.issn.1003-3289.2020.10.021
- VernacularTitle: 术前MRI评估软组织肉瘤根治术后预后
- Author:
Huici ZHU
1
Author Information
1. Department of Medical Imaging, Peking Cancer Hospital Peking Institute for Cancer Research, Key Laboratory of Ministry of Education of Carcinogenesis and Translational Research
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Prognosis;
Soft tissue neoplasms
- From:
Chinese Journal of Medical Imaging Technology
2020;36(10):1521-1526
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the value of preoperative MRI in evaluating prognosis of resectable soft tissue sarcomas (STS) after surgery. Methods: Data of 70 STS patients confirmed pathologically who underwent radical surgery and preoperative MRI were retrospectively analyzed. The tumor sizes were measured, signal intensity heterogeneity at T2WI, tumor enhancement, peritumoral edema, peritumoral enhancement, vascular/nerve or bone invasion and other signs on MRI were evaluated. The progression free survival (PFS) were evaluated, and the impact factors of PFS after radical surgery of STS were analyzed by using univariate and multivariate analyses. Results: Among 70 patients, local relapses and metastatic relapses occurred in 14 (14/70, 20.00%) and 22 cases (22/70, 31.43%) during follow-up. The median progression time was 22 months, and 1-, 2- and 3- year PFS was 62.86% (44/70), 51.43% (36/70) and 51.43% (36/70), respectively. Age, histological grade, preoperative therapy, the longest diameter of tumor, signal intensity heterogeneity at T2WI, peritumoral edema, peritumoral enhancement, vascular/nerve or bone invasion, tail sign and intercompartmental extension were the impact factors for PFS of STS after radical surgery (all P<0.05). The longest diameter of tumor, peritumoral enhancement and vascular/nerve or bone invasion were independent predictors for PFS of STS patients after radical surgery (all P<0.05). Conclusion: MRI had important predictive value for prognosis of resectable STS. The longest diameter of tumor, peritumoral enhancement and vascular/nerve or bone invasion were independent predictors for PFS of STS patients after radical surgery.
