Evaluation of liver function with hepatocyte fraction based on Gd-EOB-DTPA-enhanced liver MRI
10.13929/j.issn.1003-3289.2020.10.012
- VernacularTitle: 基于钆塞酸二钠增强MRI肝细胞分数评估肝脏储备功能
- Author:
Maotong LIU
1
Author Information
1. Department of Imaging, Nantong 3rd Hospital Affiliated to Nantong University
- Publication Type:Journal Article
- Keywords:
Contrast media;
Liver function;
Magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2020;36(10):1490-1494
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of hepatocyte fraction (HeF) based on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) enhanced liver MRI for evaluating liver function. Methods: A total of 82 patients with a history of chronic vira hepatitis B or suspected focal liver lesions underwent upper abdominal MRI were collected. The patients were divided into model for end-stage liver disease (MELD)≤10 group (n=61) and MELD>10 group (n=21) according to the MELD score of end-stage liver disease model. T1 mapping imaging was collected before and 20 minutes after Gd-EOB-DTPA administration, and parameters including precontrast and postcontrast T1 values of the liver (T1pre and T1post), the increase of T1 relaxation rate (ΔR1), the decrease rate of T1 relaxation time (ΔT1), HeF and K value were obtained and compared between 2 groups. For the parameters being statistically different between groups, multivariate Logistic regression was used to analyze the important predictors of liver function MELD>10. The correlations between each parameter and MELD score were analyzed, and the diagnostic efficacy of each parameter in differential diagnosis of patients with different liver function was evaluated by using ROC curve. Results: There were significant differences of all parameters but T1pre between 2 groups (all P<0.05). Regression analysis showed that K value was important predictive factor of MELD score >10 (P=0.01). Both T1pre and T1post were positively correlated with MELD score (r=0.46, 0.73, both P<0.01), while ΔT1, ΔR1, HeF and K value were negatively correlated with MELD score (r=-0.60, -0.52, -0.73, -0.49, all P<0.01). AUC of HeF, K value, T1post, ΔT1 and ΔR1 for identifying patients with different liver function was 0.77, 0.84, 0.75, 0.75 and 0.77 (all P=0.01), respectively. Conclusion: HeF and other parameters based on Gd-EOB-DTPA enhanced liver MRI could be used to evaluate liver function.
