A case of adrenocortical adenoma with primary hyperaldosteronism and subclinical Cushing's syndrome.
- Author:
Byung Hee HWANG
1
;
Ji Youn YU
;
Jin Hwan JUNG
;
Sung Rae KIM
;
Soon Jib YOO
;
Sung Koo KANG
;
Seong Su LEE
Author Information
1. Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea. kimsungrae@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Adrenocortical adenoma;
Cushing's syndrome;
Hyperaldosteronism
- MeSH:
Adenoma;
Adrenal Glands;
Adrenocortical Adenoma;
Adult;
Aldosterone;
Cushing Syndrome;
Dexamethasone;
Female;
Humans;
Hydrocortisone;
Hyperaldosteronism;
Hypertension;
Hypokalemia;
Plasma;
Renin
- From:Korean Journal of Medicine
2010;79(3):321-326
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cases of combined primary hyperaldosteronism and subclinical Cushing's syndrome are extremely rare. We identified a left adrenocortical tumor in a 41-year-old woman by computed tomography (CT) during an evaluation for hypokalemia and hypertension. Hormonal assessment demonstrated normal aldosterone concentrations, low plasma renin activity, an increased aldosterone/renin ratio, and normal serum cortisol levels. Selective adrenal venous sampling for the determination of aldosterone concentrations showed an overfunctioning left adrenal gland. Dexamethasone (overnight 1mg, 2 mg, 8 mg) suppression tests showed insuppressible cortisol. We diagnosed the patient as having an aldosterone-producing adrenal adenoma associated with subclinical Cushing's syndrome.
