In vitro drug release characteristics of in situ phytantriol liquid crystalline for hepatical arterial embolization
- Author:
Ke HAN
1
Author Information
1. School of Pharmaceutical Sciences
- Publication Type:Journal Article
- Keywords:
Docetaxel;
In vitro release;
Liquid crystalline;
Phytantriol
- From:
Chinese Pharmaceutical Journal
2012;47(3):213-217
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the in vitro drug release characteristics of in situ phytantriol liquid crystalline for hepatical arterial embolization. METHODS: The release study was conducted using dialysis membrane tubing. The influences of initial compositions of in situ phytantriol liquid crystalline, drug loading, iodinated oil and rotation speed on dissolution behaviour were investigated respectively using docetaxel as the model drug. Moreover, the elasticity of phytantriol liquid crystalline was investigated by rheo-logical measurement. RESULTS: The in vitro release profile could be described by Higuchi model. No significant difference in drug release behaviour was observed under different rotation speed. Nevertheless, the drug release rate decreased with increasing drug loading and phytantriol content. Furthermore, iodinated oil was found to relive the burst effect to a certain extent. And the maximal pressure load of phytantriol liquid crystalline was (3070 ± 2.135) Pa. CONCLUSION: The in situ phytantriol liquid crystalline can sustainedly release drug for up to 30 d and has good elasticity, which suggests that the in situ phytantriol liquid crystalline can be hopefully applied in clinic for combination of embolization and chemotherapy. Copyright 2012 by the Chinese Pharmaceutical Association.
