Study on chemical constituents of Zornia diphylla
- Author:
Feng-Zhi REN
1
Author Information
1. New Drug Research and Development Center of North China Pharmaceutical Group Corporation
- Publication Type:Journal Article
- Keywords:
Anti-tumor activity;
Chemical constituents;
Isoflavones;
Zornia diphylla (L.) Pers.
- From:
Chinese Pharmaceutical Journal
2012;47(3):179-181
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the chemical constituents of Zornia diphylla (L.) Pers. METHODS: were isolated by chromatography on silica gel, Sephdex LH20, ODS C-18 and HPLC, and their structures were elucidated on the basis of spectral analysis. MTT assay in vitro was used to explore the inhibiting effect of the compounds on TE13 cancer cells and B16 cancer cells. RESULTS: Six compounds were isolated and identified as 7, 4'-dimethoxy isoflavone (1); 7-hydroxy-4'-methoxyisoflavone (2); 7, 3'-dihydroxy-4'-methoxyisoflavone (3); 7, 8-dihydroxy-4'-methoxyisoflavone (4); 7, 4'-dihydroxy-8-methoxyisoflavone (5); and 7, 4'-dihydroxy-isoflavone(6). All compounds showed anti-tumor activities against the cancer cells. CONCLUSION: All compounds are isolated from Zornia diphylla (L.) Pers. for the first time. Compounds 1-6 show inhibitory activity on TE13 cancer cells, and compound 3 shows inhibitory activity on B16 cancer cells. Copyright 2012 by the Chinese Pharmaceutical Association.
