In vitro stability of Shuxuening with representative infusion solutions
- Author:
Zhi-Ying YU
1
Author Information
1. People's Hospital
- Publication Type:Journal Article
- Keywords:
Compatible stability;
Ginkgo flavonglycosides;
Ginkgolides;
Shuxuening injection
- From:
Chinese Pharmaceutical Journal
2012;47(6):467-470
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: Compatible stability of Shuxuening injection with 5 different infusions and glucose injection with insulin. METHODS: Taking Shuxuening injection with 5 different injections and glucose injection with insulin at room temperature, according to the clinical application of dose, study the compatible stability of solution with color, pH, particulates, contents of flavonoid compounds, total lactones, ginkgolides A, B and C. RESULTS: Compatibility of the solution within 12 h, the solution pH and color, compared with begin, showed no change; number of insoluble particles, ≥ 10 and 25 μm size were acceptable; flavonoid fingerprint did not change significantly; ginkgolide A, B, C and total lactone content did not change. CONCLUSION: Shuxuening injection was stable for up to 12 h in vitro in 5 different solutions and glucose injection with insulin at room temperature. Therefore, Shuxuening injection can be constituted, mixed with experiment infusion fluids. Copyright 2012 by the Chinese Pharmaceutical Association.
