Effect of furazolidone on the pharmacokinetics of lansoprazole and its metabolites in rats
- Author:
Dao-Chun XIANG
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
5-hydroxylansoprazole;
Furazolidone;
Lansoprazole;
Lansoprazole sulfone
- From:
Chinese Pharmaceutical Journal
2012;47(6):458-461
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the effect of furazolidone on the pharmacokinetics of lansoprazole in rats. METHODS: Plasma concentrations of lansoprazole and its metabolites, 5-hydroxylansoprazole and lansoprazole sulfone, were determined by HPLC-MS/ MS, and the pharmacokinetic parameters were calculated. RESULTS: The pharmacokinetic parameters showed that furazolidone (40 mg · kg-1) remarkably increased the AUC0-4h of lansoprazole from (487.33 ± 122.40) to (779.82 ± 126.67) remarkably (P < 0.05), and significantly decreased the AUC0-4h ratios of lansoprazole sulfone/lansoprazole from (0.70 ± 0.34) to (0.33 ± 0.09) (P < 0.05). CONCLUSION: Furazolidone inhibits the metabolism of lansoprazole via CYP3A4, and consequently improves the bioavailability of lansoprazole. Copyright 2012 by the Chinese Pharmaceutical Association.
