Transport of progesterone and its proliposome in Caco-2 cells monolayer
- Author:
Mei WANG
1
Author Information
1. Pharmacy Department of Xinjiang Medical University
- Publication Type:Journal Article
- Keywords:
Caco-2 cell;
Iposome;
Progesterone;
Transport
- From:
Chinese Pharmaceutical Journal
2012;47(7):529-533
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the absorption mechanism of progesterone and its proliposome in gastrointestinal (GI) tract. METHODS: Caco-2 cells monolayer was employed to investigate the transport of progesterone and its proliposome, and the effect of transport time, the drug concentration and inhibitors (cyclosporine and verapamil) on progesterone transport was further conducted. RESULTS: The apparent permeability coefficient of progesterone changed with the variety of the drug concentration, and inhibitors could improve the accumulative transport flux and the apparent permeability coefficient of progesterone. Liposome could also increase the transport of progesterone. But the transport of progesterone liposome was complied with a passive diffusion. CONCLUSION: The absorption process of progesterone is affected by P-gp, which may lead to its low bioavailability. As progesterone belongs to the second kind drugs in biopharmaceutical classification system, its bioavailability can be improved as the solubility is increased. Liposome can also improve its absorption and bioavailability through changing its absorption mechanism, which means the transport could be a passive diffusion. Copyright 2012 by the Chinese Pharmaceutical Association.
