Study on adsorption of ten injectable drugs by eight kinds of disposable filter membranes for infusion apparatus
- Author:
Yu-Guo BAI
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Esmolol;
HPLC-MS/MS;
Injectable drugs;
One-off membranes;
Sorption;
Verapamil
- From:
Chinese Pharmaceutical Journal
2012;47(8):634-638
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the absorbability of 8 kinds of disposable filter membranes for infusion apparatus to 10 injectable drugs, thus to provide information for clinical medication. METHODS: Each drug was separately dissolved in 250 mL 5% dextrose solution. Samples of drug solutions were collected before and after being filtered by the membranes. These samples were analyzed by HPLC-MS/MS methods. RESULTS: The 8 kinds of membranes had different adsorbabilities to the 10 injectable drugs. CN-CA membrane (CN-CA) and CN-CA Enhance membrane (CN-CA-E) adsorbed more drugs than other membranes (P<0.05). The average adsorption of PES membrane, NL-B membrane and ION membrane to the 10 drugs were lower than 1%. PP membrane and NL membrane to the 10 drugs were lower than 1.5%. CONCLUSION: PES membrane, ION membrane and NL-B membrane have lower adsorbabilityies than other membranes, thus may have little influence on medical treatment. They may be suitable for clinical application. Copyright 2012 by the Chinese Pharmaceutical Association.
