Biotransformation of polydatin by rat intestinal bacteria
- Author:
Wen-Ting ZHANG
1
Author Information
1. Zhejiang Institute for Food and Drug Control
- Publication Type:Journal Article
- Keywords:
Biotransformation;
Intestinal bacteria metabolism;
Polydatin;
Resveratrol
- From:
Chinese Pharmaceutical Journal
2012;47(8):631-634
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the gastrointestinal metabolic transformation of polydatin, one of the main bioactive components in Rhizoma Polygoni, thus to figure out the possible biological modification exerted by rat intestinal bacteria in vitro and in vivo, and to determine the possible metabolites. METHODS: The biological samples were analyzed by high performance liquid chromatography (HPLC) and liquid chromatography mass spectrometer (LC-MS/MS) after treatments, respectively. RESULTS: Two main compounds, polydatin and resveratrol, were identified in rat gastrointestinal contents 4 h after the ig administration of polydatin 1500 mg·kg-1. CONCLUSION: This study revealed that polydatin could be metabolized to resveratrol by rat intestinal bacteria through desugarization. Copyright 2012 by the Chinese Pharmaceutical Association.
