Effectiveness of edaravone for survival of patients with acute cerebral trauma: a meta-analysis of seven domestic studies
- Author:
Kui-Po YAN
1
Author Information
1. Institute of Integrated Traditional Medicine and Western Medicine
- Publication Type:Journal Article
- Keywords:
Acute cerebral trauma;
Edaravone;
Meta-analysis;
Survival rate
- From:
Chinese Pharmaceutical Journal
2012;47(9):731-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the effectiveness of edaravone for survival of patients with acute cerebral trauma by meta-analysis, in order to give some evidence for dealing acute cerebral trauma. METHODS: Studies that strictly followed and compared the effects of conventional treatments in combination with edaravone and conventional treatments on the survival of patients with acute cerebral trauma were searched. The qualities of the studies were evaluated. Then a meta-analysis was carried out on the qualified studies. The odds ratio (OR) for death of the two treatment regiments was calculate. The effectiveness of edaravone for prolonging the survival of patients with acute cerebral trauma was evaluated. RevMan4.2 software was applied to process data. RESULTS: Totally 7 studies including 427 cases were analyzed. There were 219 patients who received conventional treatments in combination with edaravone, among whom 47 died; while in conventional treatments group there were 208 patients and 70 died. The pooled OR was 0.50 (95% confidence interval 0.32-0.79). CONCLUSION: From the existing clinical evidence, the combination of conventional treatments with edaravone can provide some benefit for the survival of patients with acute cerebral trauma. The overall OR for death decreased by 0.50 in patients receiving combination treatment compared with that for conventional treatments. However, large-scale randomized controlled trials with rigorous design are still needed to verify and support its clinical effectiveness. Copyright 2012 by the Chinese Pharmaceutical Association.
