Familial Clustering of Type 2 Diabetes in Korean Women with Gestational Diabetes Mellitus.
10.3904/kjim.2010.25.3.269
- Author:
Sang Youl RHEE
1
;
Joo Young KIM
;
Jeong Taek WOO
;
Young Seol KIM
;
Sung Hoon KIM
Author Information
1. Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Diabetes, gestational;
Diabetes mellitus, type 2;
Cluster analysis
- MeSH:
Adult;
Cluster Analysis;
Diabetes Mellitus, Type 2/*genetics;
Diabetes, Gestational/diagnosis/*genetics;
Female;
Genetic Predisposition to Disease;
Glucose Tolerance Test;
Humans;
Korea;
Male;
Parents;
Pregnancy;
Risk Factors;
Siblings
- From:The Korean Journal of Internal Medicine
2010;25(3):269-272
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: This study was conducted to examine the relationship between family history of type 2 diabetes (T2DM) and risk of developing gestational diabetes mellitus (GDM) in Korean women. METHODS: We performed a 100-g oral glucose tolerance test in 858 pregnant women who had abnormal glucose tolerance in 50-g oral glucose challenge. In addition, we reviewed the incidence of T2DM in the parents and siblings and analyzed the association between the familial history of T2DM and the risk of GDM. RESULTS: Of the 858 subjects, 427 were normal, and 431 were diagnosed with GDM. Compared with women with no family history of T2DM, women with first degree family history of T2DM displayed higher risk of T2DM (odd ratio: parent only 1.91, sibling only 6.24, any 2.27). CONCLUSIONS: The risk of developing GDM was significantly increased in Korean women with a family history of T2DM in first-degree relatives.
