Optimization of extraction technology of Schisandrae Chinensis Fructus by Multi-objective Genetic Algorithm
- Author:
Yan-Jie XU
1
Author Information
1. Department of Health Statistics
- Publication Type:Journal Article
- Keywords:
Extraction technology;
Genetic algorithm;
Multi-objective optimization;
Pareto non-inferior solution;
Schisandrae Chinensis Fructus;
Schizandrin;
Thetotal lignan;
Uniform design
- From:
Chinese Pharmaceutical Journal
2012;47(9):669-673
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the application of Multi-objective Genetic Algorithm in optimization of micro-extraction technology of Schisandrae Chinensis Fructus. METHODS: Sub-target model of extraction rate, schizandrin and the total lignan was established based on micro-extraction Schisandrae Chinensis Fructus experimental data resulted from uniform design. Applying MOGA, the optimal extracting conditions were explored, and the results were compared with those of Single-objective genetic algorithm. Using SGALAB beta5008 of the Matlab2009a plug-in tool-box, the genetic algorithm optimization was achieved. SPSS13.0 software was used for statistical analysis. RESULTS: The optimal conditions were as follows; microwave power 270 W, ethanol 87%, extraction time 7 min, ethanol amount 1:4.5, grinding degree 70. Under these conditions, the extract rate was 21.40%, Schizandrin recovery was 4.72%, and the total lignan recovery was 10.84%. CONCLUSION: MOGA provides a reasonable pareto ensuring the optimal multi-objective, which provides a reasonable method for extraction of Schisandrae Chinensis Fructus. This method can be applied in the selection of extraction technology of other drugs. Copyright 2012 by the Chinese Pharmaceutical Association.
