A systematic review of ambroxol hydrochloride in patients with meconium aspiration syndrome
- Author:
Xi YIN
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Ambroxol hydrochloride;
Infant;
Meconium aspiration syndrome;
Meta-analysis
- From:
Chinese Pharmaceutical Journal
2012;47(10):776-781
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To review the efficacy and safety of ambroxol hydrochloride in the treatment of meconium aspiration syndrome by evidence based medicine methods. METHODS: Databases of Medline, EMBase, the Cochrane library, ISI database, CBM, VIP, wanfang, and CNKI were searched. Studies of randomized controlled trials (RCT) of ambroxol hydrochloride in the treatment of meconium aspiration syndrome were included for quality analysis and meta-analysis. RESULTS: Eleven RCTs were included.Meta-analysis indicated that there was significant difference between ambroxol hydrochloride and conventional treatment in cure rates, oxygen therapy, hospital stay with RR values (MD values) and 95% CIs of 1.29 (1.11, 1.48), -10.71 (-15.87, -5.55), and -3.12 (-4.81, -1.43), respectively. The death rates had no significant difference. CONCLUSION: Based on the recent evidence, ambroxol hydrochloride treatment can achieve better prognosis in patients with meconium aspiration syndrome. Due to its safety and reliable efficacy, this drug can be recommended for treating patients with meconium aspiration syndrome. Copyright 2012 by the Chinese Pharmaceutical Association.
