Effects of electrical factors and pH of donor chamber solution on transdermal iontophoresis of ciprofloxacin
- Author:
Yu-Yun TONG
1
Author Information
1. The First People's Hospital of Yongkang
- Publication Type:Journal Article
- Keywords:
Ciprofloxacin;
Electrical factor;
Enhancement ratio;
Iontophoresis;
PH
- From:
Chinese Pharmaceutical Journal
2012;47(13):1056-1059
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effects of current, voltage and pH of donor chamber solution on the iontophoretic transport of ciprofloxacin. METHODS: An in vitro study was carried out to determine the iontophoretic permeability of ciprofloxacin through pig skin. Iontophoretic flux of ciprofloxacin through excised pig skin was determined using Valia-Chien two chamber diffusion cells. The permeability enhancement ratios in donor chamber solution of different pH under different currents and voltages were also measured. RESULTS: Iontophoretic flux of ciprofloxacin increased with increasing current and voltage. The effect of ciprofloxacin solution pH in the donor chamber on the iontophoretic transport was observed. When the pH of ciprofloxacin solution was 3.5, there was good iontophoretic permeability. CONCLUSION: The results suggest that electrical factor and pH of the donor chamber solution may be important factors for the iontophoretic permeability of ciprofloxacin.
