Efficacy and safety of ambroxol for lung protection in perioperative period: A systematic review
- Author:
Na SU
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Ambroxol;
Lung protection;
Meta-analysis
- From:
Chinese Pharmaceutical Journal
2012;47(14):1154-1157
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To review the efficacy and safety of ambroxol for lung protection in perioperative period. METHODS: Random controlled trails (RCTs), systematic review (SR), and meta-analysis of ambroxol for lung protection in perioperative period were searched in Cochrane, PubMed, Embase, ISI, CBMdisc, CNKI, VIP and Wangfang dababase; the methodology quality of every RCT was evaluated, then meta-analysis was performed by software of RevMan5.0.0. RESULTS: Twelve RCTs of ambroxol for lung protection in perioperative period were included. According to the meta-analysis results, the ambroxol group was better than the control group in pulmonary complications [RR 0.55,95% CI(0.40, 0.74), P=0.0001], The cough and expectoration degree in the ambroxol group was better than the control group [RR 1.25, 95% CI (1.09, 1.44), P=0.001]. The ambroxol group was also better than the control group in sputum volume [RR 1.24,95% CI(1.12, 1.38), P < 0.00001]. ADR had no significant difference between the ambroxol and control groups. CONCLUSION: Using ambroxol for lung protection in perioperative period can improve post-operativer-espiratory system symptoms and reduce pulmonary complications. Ambroxol has a satisfactory lung protective effect in the preoperative period. Copyright 2012 by the Chinese Pharmaceutical Association.
