Synthesis of levamisole ferulate and its effects on immune function of mice
- Author:
Jian-Hua WANG
1
Author Information
1. Bioengineering College
- Publication Type:Journal Article
- Keywords:
Cyclophosphamide;
Immune function;
Immune organ index;
Levamisole ferulate;
Mice;
Structure modification
- From:
Chinese Pharmaceutical Journal
2012;47(15):1257-1262
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare levamisole ferulate (LF) and investigate its effects on the immune function of mice with low immunity, thus to provide basic evidence for regulation of the immune status of animals and improvement of body's defense. METHODS: LF was synthesized by levamisole hydrochloride and sodium ferulate. The model of immune inhibited mice was established by intraperitoneal injection with cyclophosphamide (CTX). In order to verify and compare the effect of immune enhancement, a series of parameters were determined such as the immune organ index, the serum IgA, IgG and IgM in cyclophosphamide-induced-immunosu-pressed mice. RESULTS: The product was obtained and its yield was 80.49%. The identification of the product was done by means of elemental analysis, TLC, UV-Vis, IR and ESI-MS. LF significantly increased the contents of IgM and IgG in cyclophosphamide-in-duced-immunosupressed mice and improved the thymus and spleen indexes. CONCLUSION: This synthetic technique is simple and feasible. LF can significantly regulate the immune function in mice. Copyright 2012 by the Chinese Pharmaceutical Association.
