Antihypertensive effects of biodegradable microspheres loaded with recombinant antihypertensive peptide in spontaneously hypertensive rats
- Author:
Hai-Yan SUN
1
Author Information
1. Shenzhen Polytechnic
- Publication Type:Journal Article
- Keywords:
Biodegradable microspheres;
Recombinant antihypertensive peptide;
Spontaneously hypertensive rats;
Systolic blood pressure
- From:
Chinese Pharmaceutical Journal
2012;47(16):1288-1291
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of PLGA microspheres loaded with recombinant antihypertensive peptide (rAHP) on blood pressure of spontaneously hypertensive rats (SHR). METHODS: SHR were randomized to ten groups (n=8 in each group) and administered saline, rAHP (800 μg · kg-1) or rAHP-PLGA microspheres (200, 400 and 800 μg · kg-1) by gavage and subcutaneous injection respectively. WKY rats were randomized to four groups (n=8 in each group) and given rAHP-PLGA microspheres (800 μg · kg-1) or saline by gavage and subcutaneous injection respectively. The systolic blood pressure was measured before and after the administration. RESULTS: Compared with the control group, medium-dose and high-dose of rAHP-PLGA microspheres reduced blood pressure after being orally administered and the effect lasted for above 30 h. For the subcutaneous injection groups, medium-dose and high-dose of rAHP-PLGA microspheres reduced blood pressure and the effect lasted for above 8 d. rAHP-PLGA microspheres had no effect on blood pressure in WKY rats. CONCLUSION: rAHP-PLGA microspheres have long-lasting and significant anti-hypertensive effect in SHR. Copyright 2012 by the Chinese Pharmaceutical Association.
