Anti-inflammation effect of curcumin and its derivatives in vivo
- Author:
Ji-Xiao LI
1
Author Information
1. Pharmacy College
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Anti-oxidant;
Curcumin derivatives;
Curvumin;
PGE2
- From:
Chinese Pharmaceutical Journal
2012;47(17):1374-1377
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the anti-inflammation effect of curcumin and its derivative in vivo. METHODS: Observations were made on the anti-inflammatory effect of curcumin and its derivatives in xylene-induced mouse ear edema and carrageenan-induced paw edema. The plasma T-AOC, MDA and tissue PGE2 levels were measured. RESULTS: Xylene-induced mouse ear edema and carrageenan-induced paw edema were improved by curcumin and its derivatives in different degrees (P < 0.05, P < 0.01), the plasma MDA levels were lowered, the T-AOC levels were increased, meanwhile PGE2 synthesis in the inflammatory tissues were inhibited (P < 0.05, P < 0.01). CONCLUSION: The anti-inflammatory activity of curcumin and its derivatives in mice may be related to increasing antioxidant capacity and inhibiting the PGE2 synthesis. Copyright 2012 by the Chinese Pharmaceutical Association.
