Properties of polyacrylic resin Eudragit L100 and Eudragit S100 free film
- Author:
Shuang-Qing ZHANG
1
Author Information
1. Laboratory of Drug Metabolism and Pharmacokinetics
- Publication Type:Journal Article
- Keywords:
Eudragit S100;
Free film;
Permeability;
Polyacrylic resin Eudragit L100;
Solubility parameter;
Tensile strength
- From:
Chinese Pharmaceutical Journal
2012;47(18):1489-1492
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the properties of polyacrylic: resin Eudragit L100-Eudragit S100 (mixed at ratio of 1:4) free film and its various influencing factors. METHODS: The free film was prepared by casting method,and its solubility parameter, intrinsic viscosity, tensile strength and permeability were determined. The optimal solvent and plaslicizer were screened. RESULTS: The tensile strength of the film prepared by ethanol was maximum, and the permeability of the free film made using acetone was the highest, therefore ethanol was the optimal solvent. Plasticizer could decrease the tensile strength and increase the permeability of free film,and diethyl phthalate was the optimal plasticizer. CONCLUSION: The present investigation might be helpful for screening coating formulation and optimizing coating process.
