Synthesis and cytotoxicity study of N-benzyl-3, 5-bis(arylmethylene)-4-piperidones
- Author:
Ju-Feng SUN
1
Author Information
1. School of Pharmacy
- Publication Type:Journal Article
- Keywords:
Aldol condensation reaction;
Benzaldehyde derivatives;
Cytotoxicity;
Multi-Drug-resistance reverting properties;
N-benzyl-3, 5-bis(arylmethylene)-4-piperidone
- From:
Chinese Pharmaceutical Journal
2012;47(19):1588-1591
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To synthesize a kind of novel cytotoxin with multi-drug-resistance reverting properties and study their cytotoxicity. METHODS: The target compounds were obtained from N-benzyl-4-piperidones and benzaldehyde derivatives on the condition of 20°C, 7-8 h, taking dry hydrogen chloride as catalyst, using aldol condensation reaction, inspected by TLC and purified through recrystallization. RESULTS: Five N-benzyl-3, 5-bis(arylmethylene)-4-piperidone derivatives were synthesized. The yield was over 49%. Their structures were characterized by 1H-NMR, ESI-MS with melting points. The data of cytotoxicity was obtained. CONCLUSION: The synthetic route is convenient and efficient; The compounds had good inhibiting activity for a few kinds of tumor cells. Copyright 2012 by the Chinese Pharmaceutical Association.
